1.
J Chem Inf Model
; 61(9): 4152-4155, 2021 09 27.
Article
in English
| MEDLINE | ID: covidwho-1392764
ABSTRACT
The emergence of variants of SARS-CoV-2 with mutations in their spike protein are a major cause for concern for the efficacy of vaccines and control of the pandemic. We show that mutations in the spike protein of SARS-CoV-2 are selecting for amino acid changes that result in a more thermodynamically stable protein than expected from background. We suggest that the computationally efficient analysis of mutational stability may aid in early screening of variants.
Subject(s)
COVID-19 , SARS-CoV-2 , Humans , Mutation , Protein Stability , Spike Glycoprotein, Coronavirus/genetics
2.
Oral Oncology
; 118:7-7, 2021.
Article
in English
| Academic Search Complete | ID: covidwho-1287673
3.
Clin Otolaryngol
; 46(6): 1237-1241, 2021 11.
Article
in English
| MEDLINE | ID: covidwho-1258916